Major Clinical Depression - any new meds or help out there?

I was diagnosed with major clinical dep. a few yrs. ago and have tried numerous medications. It started out as just major fatigue and the doctors I have seen all jumped straight to depression as the cause and put me on different meds (I have tried at least 8-10 meds) nothing has helped so far. I have also been in counseling with the meds. The only thing that seems to help the fatigue and depressed mood is Ultram (I know this is just supposed to be for pain and I haven't been taking it for the right reason but for some reason it helps) - I have been taking way too much of it for a long time because I don't know what else to do. I am so tired of going to different docs and they all just guess at what meds to put me on - I was on Provigil for the fatigue for about 6 mnths (it was great) then it stopped working. I am trying to get my kids back (taken by the state of TN for "neglect" although there was NO neglect - long story), keep my job and home, and keep my marriage together. Pls help!